The Impact of Serum and Follicular Fluid Irisin on Oocyte and Embryonic Characteristics in Infertile Women Undergoing ICSI According to BMI

Background: Irisin is a recently identified myokine that acts like adipokines. It has been revealed to be connected with insulin resistance (IR), obesity, and metabolic syndrome. Objective: To investigate serum, follicular fluid (FF), irisin, IR in lean, overweight, obese women undergoing the intracytoplasmic sperm injection (ICSI) cycle correlate them oocyte embryo quality. Methods: Ninety infertile Iraqi aged 18 40 years had primary or secondary infertility. They were enrolled this study divided into three groups according body mass index ranking: first group: twenty-seven normal-weight females, second thirty-five overweight third twenty-eight females. ICSI was done for evaluate level of serum Homeostatic Model Assessment Insulin Resistance (HOMA-IR) at day pickup outcome. Results: HOMI-IR, FF levels significantly higher people. Also, there significant difference between regard MII, maturity rate, grade 1 embryo, pregnancy outcome, which less group. In addition, negative correlation HOMI-IR irisin MII count, 1, Conclusion: Serum, Irisin, HOMA-IR cases than lean cases, may cause reduction